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Meet the Expert
Novas Terapêuticas Centrais para o tratamento da disfunção eréctil

 
Centro de Formação do Hospital de Santo António, Porto
14 de Dezembro 2007
 

 

MODERADOR
Prof. Doutor La Fuente Carvalho
Hospital de Santo António
Presidente da Sociedade Portuguesa de Andrologia

COMENTADOR
Dr. Joaquim Lindoro
Hospital Padre Américo


Prof. ARGIOLAS’s brief CV

ANTONIO ARGIOLAS is full professor of Physiologic Psychology, and Dean of the School of Psychology of the University of Cagliari. He works in the Department of Neuroscience of the University of Cagliari since 1975, when the Department of Neuroscience was called Institute of Pharmacology of the Faculty of Medicine and Surgery. He worked for three years as a visiting associate in the National Lung, Blood and Heart Institute, National Institutes of Health a Bethesda (USA). His scientific activity is documented by more than 160 articles, the majority of them published in international scientific journals. These articles can be divided in 4 groups organized in 4 principal research themes:

1) function of dopaminergic systems in different physiological and pharmacological conditions;

2) identification of bioactive peptides from natural sources;

3) role of neurotransmitters and neuropeptides in the control of erectile function and sexual behavior, and

4) neurohypophyseal peptides in the thymus gland.

The last 20 years articles belong almost all to the 3rd line of research and revealed a key role of oxytocinergic transmission and of nitric oxide at the level of the paraventricular nucleus of the hypothalamus (PVN) in the control of penile erection and sexual behavior in physiological conditions. During previous Nationally Relevant Research Projects as national coordinator (1997, 2000 and 2005) and a national FIRB 2001 research project all granted by the Italian Ministry of the University and Research, studies made in the Research Unity directed by prof. Argiolas, two new classes of peptides (one endogenously present in the central nervous system) were characterized for their ability to induce penile erection when injected into the PVN. Also these peptides (growth hormone secretagogues and peptides derived from VGF protein) induce erectile response by activating oxytocinergic neurotransmission at the PVN level.